Frailty in mouse ageing: A conceptual approach

von Zglinicki T, Nieto IV, Brites D, Karagianni N, Ortolano S, Georgopoulos S, Cardoso AL, Novella S, Lepperdinger G, Trendelenburg AU, et al. Mech Ageing Dev. 2016 Jul 18. pii: S0047-6374(16)30109-9. doi: 10.1016/j.mad.2016.07.004. [Epub ahead of print] Review. PubMed PMID: 27443148.

Abstract: Human life expectancy has increased dramatically in the last century and as a result also the prevalence of a variety of age-related diseases and syndromes. One such syndrome is frailty, which is defined asa combination of organ dysfunctions leading to increased vulnerability to adverse health outcomes. Inhumans, frailty is associated with various biomarkers of ageing and predicts relevant outcomes suchas responses to therapies and progression of health status and mortality. Moreover, it is relatively easyto assess. To foster translation of mechanistic understanding of the ageing process and, importantly, ofinterventions that may extend healthy lifespan, frailty scales have been reverse translated into mice inrecent years. We will review these approaches with a view to identify what is known and what is notknown at present about their validity, reproducibility and reliability with a focus on the potential forfurther improvement......  Read the article here >

 

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