Publications

Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis

Biomedcode scientists coauthor a publication in JCI insight showing that TNFΔARE mice develop mesenchymal cell dependent heart valve pathology with...

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Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated...

Biomedcode scientists coauthor a publication in Annals of Rheumatic diseases showing that Tg197 mice develop heart valve pathology sharing common...

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Targeted metabolic profiling of the Tg197 mouse model reveals itaconic acid as a marker of Rheumatoid...

Biomedcode coauthors a publication on the identification of a biomarker with translational value for the diagnosis & monitoring of rheumatoid...

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Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator...

Biomedcode's human TNF transgenic arthritis model, (Tg197), contributes to the non-clinical assessment of etanercept biosimilar GP2015 with...

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Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of...

Biomedcode's mouse models offered the in vivo non-clinical proof validating the efficacy of a novel composite hydrogel tacrolimus formulation for...

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Frailty in mouse ageing: A conceptual approach

von Zglinicki T, Nieto IV, Brites D, Karagianni N, Ortolano S, Georgopoulos S, Cardoso AL, Novella S, Lepperdinger G, Trendelenburg AU, et al. Mech...

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Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody...

Goodall LJ, Ovecka M, Rycroft D, Friel SL, Sanderson A, Mistry P, Davies ML, Stoop AA. PLoS One. 2015 Sep 9;10(9)

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Review: animal models as a tool to dissect pivotal pathways driving spondyloarthritis

The article describes systematically the clinical features, histopathology & pathophysiology of animal models

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Regulation of tumour necrosis factor signalling: live or let die

Brenner D, Blaser H, Mak TW, 2015, Nat. Rev. Immunol., May 26;15(6):362-74. doi: 10.1038/nri3834. Abstract: Tumour necrosis factor (TNF) is a...

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Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess...

UCB Celltech & Biomedcode co-author a new paper demonstrating that CAIA in the human TNF transgenic (Tg1278TNFko) mice is a well-suited animal...

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