Publications

Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis

Highlight the dominant role of subepithelial myofibroblasts in sensing inflammation and tissue damage and promoting intestinal homeostasis through...

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Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like...

The new mice model TNFΔARE of Crohn's disease overproduce TNF, specifically from the gut epithelium, causing full disease pathology in the mouse.

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Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent...

Demonstrates that development of intestinal inflammation in the TNF(DeltaARE) mice is critically dependent on beta7 integrin-mediated T-lymphocyte...

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis...

Describes the importance of tumor necrosis factor (TNF) in the development of Crohn's disease...

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Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint...

The article describes the generation and characterization of the TNFΔARE line, a unique model that develops both arthritis and Crohn’s disease....

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