Publications

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like...

The new mice model TNFΔARE of Crohn's disease overproduce TNF, specifically from the gut epithelium, causing full disease pathology in the mouse.

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Anti-TNFα domain antibody construct CEP-37247: Full antibody functionality at half the size.

A publication on a novel antibody characterization where the experiments were performed using Tg197 transgenic mouse model by Biomedcode.

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ATX expression and LPA signalling are vital for the development of the nervous system.

Embryonic expression of Autotaxin, a secreted lysophospholipase D generating lysophosphatidic acid, is necessary for vascular branching...

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Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR.

As demonstrated in this paper, HuR controls the cell cycle of immature progenitors as well as the antigenic, apoptotic and migration signals that...

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Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent...

Demonstrates that development of intestinal inflammation in the TNF(DeltaARE) mice is critically dependent on beta7 integrin-mediated T-lymphocyte...

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Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

Provides direct evidence for the role of TNF in chronic intestinal inflammation using TNBS colitis in Tg197 mice as a model and encourages further...

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Dickkopf-1 is a master regulator of joint remodeling

This article explores the role of the Wnt signalling pathway in joint remodelling process using Tg197 as RA model...

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Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis.

The paper explains the use of soluble TNF inhibitors in the treatment of Idiopathic Pulmonary Fibrosis.

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Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with...

This article describes the use of non anti TNF therapies, Diacerein and Dexamethasone in Tg197 model of arthritis. The Tg197 model can be used to...

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Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a...

This article describes the use of a non anti TNF therapeutic, a phospholipase II inhibitor inTg197 model of arthritis

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