Publications

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis...

Describes the importance of tumor necrosis factor (TNF) in the development of Crohn's disease...

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Anti-TNF-alpha antibody allows healing of joint damage in polyarthritic transgenic mice

Amelioration of established polyarthritis by treatment with anti-TNF-α mAb...

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Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint...

The article describes the generation and characterization of the TNFΔARE line, a unique model that develops both arthritis and Crohn’s disease....

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A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF...

Alexopoulou L, Pasparakis M, Kollias G., 1997, A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative...

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Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in...

The article describes the generation and phenotypic characterization of Tg5453 model of arthritis...

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Immune and Inflammatory Responses in TNFα-deficient Mice: A Critical Requirement for TNFα in the Formation...

This article shows how TNF expression from Tg1278 transgene, allows the restoration of TNF function in TNF ko mice.

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Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

Description of the generation and characterization of the Tg197 arthritis model as well as the generation of various hTNF transgenic lines...

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