Acute inflammation

Endotoxin, a cell wall component of Gram-negative bacteria, plays a central role in the pathogenesis of septic shock. Small doses of endotoxin induce in mice acute inflammatory responses similar to those  occuring during the early stages of septic shock. Within hours following the administration of endotoxin, changes occur in organ functions and inflammatory cytokines & chemokines like TNF, IL6 are released.