mouse tmTNF driven spondyloarthritis (TgA86)
TgA86 mice overexpress mouse transmembrane TNF from a Δ1-12 mTNF-globin transgene and develop chronic inflammatory arthritis pathology as early as 4 weeks of age. In addition to the peripheral pathology these mice develop spondyloarthritis which is evident in all mice by a characteristic tail bending.
X-ray scanning of a set of tail vertebrae from wt (left) and TgA86 (right) mice suggesting the presense of typical spondyloarthritis signs in TgA86 mice. Signs include inflammation, appearing as soft tissue swelling, bone erosion, indicated by loss of small connecting bones between vertebrae, new bone formation, resulting in the brighter appearence of denser bones, loss of bar-bell shape and development of rectangular shape of vertebrae in TgA86 mice.
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Biomedcode's disease models are highlighted in a new review discussing animal models of spondyloarthritis.