Preclinical Efficacy Platforms

Biomedcode is a CRO that offers in-vivo standardized preclinical platforms of arthritis, intestinal inflammation, psoriasis, osteoporosis and other inflammatory diseases, based on humanized and wild type mouse models that allow the efficacy evaluation of pharmaceuticals targeting human molecules in chronic inflammatory diseases. The services offered combine scientific consulting and custom-tailored solutions optimizing the validation procedure of novel and biosimilar pharmaceuticals as well as novel therapeutic approaches.

A combination of the services offered by Biomedcode results in unique preclinical efficacy evaluation tools that fulfil the specific needs of our clients.

Biomedcode at a glance > (pdf presentation)

The disease model

Depending on the therapeutic target evaluated, the client may choose a disease model based on a collection of humanized transgenic mice or a wild type animals.

The study design

Generation of experimental animals & group formation
Control groups
Administration route:IV, IP, SC, IM, PO, IR, etc
In vivo monitoring: measurements, clinical scoring (weight, temperature), general health status
Biological sample collection: blood, plasma, serum, urine

The assays

ELISA
Molecular & cellular assays
FACS analysis
Thick organ culture
Multiplex analysis (with external collaboration)

The histology

Gross necropsy
Tissue collection
Paraffin embedding
Histopathology slide preparation & staining
Histopathological evaluation
Immunohistochemistry

Pharmacogenomics analysis

RNA preparation
Gene expression profiling
Functional analysis
MOA