The disease model

Depending on the therapeutic target evaluated, the client may choose a disease model based on a collection of humanized transgenic mice or a wild type animals.

 

 

     The study design

  • Generation of experimental animals & group formation
  • Control groups
  • Administration route:IV, IP, SC, IM, PO, IR, etc 
  • In vivo monitoring: measurements, clinical scoring (weight, temperature), general health status
  • Biological sample collection: blood, plasma, serum, urine

 

    The assays

  • ELISA
  • Molecular & cellular assays
  • FACS analysis
  • Thick organ culture
  • Multiplex analysis (with external collaboration)

 

    The histology

  • Gross necropsy
  • Tissue collection
  • Paraffin embedding
  • Histopathology slide preparation & staining
  • Histopathological evaluation                                        
  • Immunohistochemistry

 

     Pharmacogenomics analysis

  • RNA preparation
  • Gene expression profiling   
  • Functional analysis
  • MOA