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New: TghIL23p19 transgenic mice developing dermatitis pathology

BiomedcodeBiomedcode / News / New: TghIL23p19 transgenic mice developing dermatitis pathology
11
Dec
2020
Date December 11, 2020
Categories News

New: TghIL23p19 transgenic mice developing dermatitis pathology

Biomedcode has developed a new humanized mouse line overexpressing human IL23p19. These mice develop spontaneous phenotypes including dermatitis lesions in jaw-neck area, ear thickening, enlarged draining lymph nodes, spleenomegaly and more. The skin pathology, that has features of atopic dermatitis, gets significantly ameliorated upon treatment with  anti-hIL23p19, rendering this mouse model a nice tool for the efficacy evaluation of therapeutics targeting this key molecule.

While the phenotypes are  further analyzed the dermatitis model  is available for preclinical evaluation.

 

 

 

 

 

Author biomeduser

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  • New: TghIL23p19 transgenic mice developing dermatitis pathologyDecember 11, 2020
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