Building on the experience of the members of our board of directors we are now developing an anti-osteoporotic drug efficacy evaluation platform based on a recently generated human RANKL transgenic mouse.
Rheumatoid Arthritis (RA)
Biomedcode’s unique animal models of human TNF-depended arthritis have historically offered the first proof of concept for the central role of TNF in the development of human arthritis. Today our rich collection of arthritis mouse models is widely used for the preclinical efficacy evaluation of anti-arthritic pharmaceuticals and offer an ideal platform for establishing proof of concept for novel technological advances...
Inflammatory Bowel Disease (IBD)
Biomedcode has a collection of spontaneous & induced models of IBD & colitis. TNFΔΑRΕ animals developed in 1999 by scientists from our BoD, are an ideal chronic inflammatory disease model of Crohn's disease-like pathology. In addition, Biomedcode offers induced acute models of colitis...
Multiple Sclerosis (MS)
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used experimental model for the human inflammatory demyelinating disease multiple sclerosis (MS). Biomedcode has standardized an EAE-based preclinical drug efficacy evaluation platform both in humanized and wild type animals for the evaluation of anti-human therapeutics & smal molecules...
Psoriasis is a frequently occurring inflammatory skin disorder characterized by hyper proliferating keratinocytes and massive infiltration of leukocytes. Imiquimod induced psoriasis recapitulates many important features of the psoriatic pathology and in combination to humanized transgenic mice offers the opportunity for the development of anti-psoriasis drug efficacy evaluation platforms...