White papers – Biomedcode https://www.biomedcode.com Priming drugs for success Mon, 21 Aug 2023 12:34:05 +0000 en-US hourly 1 https://www.biomedcode.com/wp-content/uploads/2019/07/32X32.png White papers – Biomedcode https://www.biomedcode.com 32 32 Tg3647 a slow progressing model of chronic arthritis https://www.biomedcode.com/white-papers/tg3647-a-slow-progressing-model-of-chronic-arthritis/ Tue, 21 Jan 2020 10:19:18 +0000 https://www.biomedcode.com/?p=10711 Tg3647 mice over-express human TNF that leads to the gradual development of spontaneous slow progressing chronic inflammatory polyarthritis with 100% penetrance. Histopathological progression of arthritis pathology with age in the Tg3647 model of arthritis    Download the whitepaper to learn more on: The disease model Study design Routes of administration Validation data Readouts Analysis options … Continue reading Tg3647 a slow progressing model of chronic arthritis

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Tg3647 mice over-express human TNF that leads to the gradual development of spontaneous slow progressing chronic inflammatory polyarthritis with 100% penetrance.

Histopathological progression of arthritis pathology with age in the Tg3647 model of arthritis

 

 Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

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]]> CAIA: an induced arthritis model for the efficacy evaluation of arthritis therapeutics https://www.biomedcode.com/white-papers/caia-an-induced-arthritis-model-for-the-efficacy-evaluation-of-arthritis-therapeutics/ Thu, 16 Jan 2020 10:23:15 +0000 https://www.biomedcode.com/?p=10715 Collagen antibody-induced arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used to address questions relating to the pathogenic mechanisms of the disease and serves as a platform for the evaluation of candidate therapeutic agents. Biomedcode has standardized the model in C57BL/6 wild type mice, Mice humanized for hTNFR1 Tg1278TNFKO human … Continue reading CAIA: an induced arthritis model for the efficacy evaluation of arthritis therapeutics

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Collagen antibody-induced arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used to address questions relating to the pathogenic mechanisms of the disease and serves as a platform for the evaluation of candidate therapeutic agents.

Biomedcode has standardized the model in

  1. C57BL/6 wild type mice,
  2. Mice humanized for hTNFR1
  3. Tg1278TNFKO human TNF transgenic mice
  4. Mice humanized for both TNF and TNFR1

and developed platforms to allow the evaluation of different arthritis therapeutics.

Representative CAIA in-vivo arthritis progression in Tg1278TNFKO animals treated prophylactically with anti-hTNF therapeutics.

 

 

Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

DOWNLOAD PDF

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]]> TgA86 a mouse model of human spondyloarthritis https://www.biomedcode.com/white-papers/tga86-a-mouse-model-of-human-spondyloarthritis/ Mon, 27 May 2019 10:11:07 +0000 https://www.biomedcode.com/?p=10709 TgA86 mice overexpress mouse transmembrane TNF from a Δ1-12 mTNF-globin transgene. They develop with 100% incidence peripheral and axial joint pathology accompanied by new bone formation features, all characteristic of human SpA pathology.   Download the whitepaper to learn more on: The disease model Study design Routes of administration Validation data Readouts Analysis options DOWNLOAD … Continue reading TgA86 a mouse model of human spondyloarthritis

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TgA86 mice overexpress mouse transmembrane TNF from a Δ1-12 mTNF-globin transgene. They develop with 100% incidence peripheral and axial joint pathology accompanied by new bone formation features, all characteristic of human SpA pathology.

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Effect of late treatment on the progression of joint (arthritis) and axial (tail) pathology

 

Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

DOWNLOAD PDF

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]]> Tg5453: a mouse model of transmembrane TNF driven arthritis https://www.biomedcode.com/white-papers/tga86-a-mouse-model-of-spondyloarthritis/ Wed, 17 Apr 2019 14:15:53 +0000 http://biomedcodewp.generation-y.net/?p=8362 Tg54531 is a transgenic mouse with transmembrane human TNF deregulated expression resulting in the spontaneous development of arthritis pathology that closely resembles human rheumatoid arthritis. The mice develop arthritis with 100% penetrance and provide a fast in-vivo model for evaluating human therapeutics targeting rheumatoid arthritis. The Tg5453 mouse model was successfully used in establishing the … Continue reading Tg5453: a mouse model of transmembrane TNF driven arthritis

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Tg54531 is a transgenic mouse with transmembrane human TNF deregulated expression resulting in the spontaneous development of arthritis pathology that closely resembles human rheumatoid arthritis.

The mice develop arthritis with 100% penetrance and provide a fast in-vivo model for evaluating human therapeutics targeting rheumatoid arthritis.

The Tg5453 mouse model was successfully used in establishing the therapeutic efficacy of Remicade®, the first anti-TNF therapeutic to be successfully applied in the clinic, and is currently used for screening anti-rheumatoid candidate drugs.

Representative graph of the progression of the in vivo arthritic score in Tg5453 animals untreated or treated with commercially available anti-hTNF therapeutics.

 

 Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

DOWNLOAD PDF

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]]> The TNFΔARE Preclinical Platform for the preclinical testing of therapeutics targeting rheumatoid arthritis and intestinal inflammation https://www.biomedcode.com/white-papers/the-tnf%ce%b4are-preclinical-platform-for-the-preclinical-testing-of-therapeutics-targeting-rheumatoid-arthritis-and-intestinal-inflammation/ Wed, 17 Apr 2019 13:57:48 +0000 http://biomedcodewp.generation-y.net/?p=8358 The TNFΔARE mouse model develops arthritis pathology together with Crohn’s like ileal inflammation with 100% penetrance. The co-occurence of two inflammatory pathologies provide a reliable in-vivo model for evaluating therapeutics targeting both pathologies. Grip strength force modulation with age in wt and TNFΔARE mice treated or not with Enbrel    Download the whitepaper to learn … Continue reading The TNFΔARE Preclinical Platform for the preclinical testing of therapeutics targeting rheumatoid arthritis and intestinal inflammation

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]]> The TNFΔARE mouse model develops arthritis pathology together with Crohn’s like ileal inflammation with 100% penetrance. The co-occurence of two inflammatory pathologies provide a reliable in-vivo model for evaluating therapeutics targeting both pathologies.

Grip strength force modulation with age in wt and TNFΔARE mice treated or not with Enbrel 

 

Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

DOWNLOAD PDF

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]]> Human TNF transgenic mouse arthritis model for the preclinical testing of human therapeutics targeting rheumatoid arthritis https://www.biomedcode.com/white-papers/human-tnf-transgenic-mouse-arthritis-model-for-the-preclinical-testing-of-human-therapeutics-targeting-rheumatoid-arthritis/ Fri, 22 Mar 2019 11:41:56 +0000 http://biomedcodewp.generation-y.net/?p=8084 The Tg197 mouse model was successfully used in establishing the therapeutic efficacy of Remicade®, the first anti-TNF therapeutic to be successfully applied in the clinic, and is recommended by the FDA for screening potential anti-rheumatoid candidate drugs. Tg197 is a transgenic mouse overexpressing human TNF resulting in the spontaneous development of arthritis whose pathology closely … Continue reading Human TNF transgenic mouse arthritis model for the preclinical testing of human therapeutics targeting rheumatoid arthritis

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]]> The Tg197 mouse model was successfully used in establishing the therapeutic efficacy of Remicade®, the first anti-TNF therapeutic to be successfully applied in the clinic, and is recommended by the FDA for screening potential anti-rheumatoid candidate drugs.

Tg197 is a transgenic mouse overexpressing human TNF resulting in the spontaneous development of arthritis whose pathology closely resembles human rheumatoid arthritis. The mice develop arthritis with 100% penetrance and provide a fast in-vivo model for evaluating human therapeutics targeting rheumatoid arthritis.

Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

DOWNLOAD PDF

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