Collagen antibody-induced arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used to address questions relating to the pathogenic mechanisms of the disease and serves as a platform for the evaluation of candidate therapeutic agents.
Biomedcode has standardized the model in
- C57BL/6 wild type mice,
- Mice humanized for hTNFR1
- Tg1278TNFKO human TNF transgenic mice
- Mice humanized for both TNF and TNFR1
and developed platforms to allow the evaluation of different arthritis therapeutics.
Representative CAIA in-vivo arthritis progression in Tg1278TNFKO animals treated prophylactically with anti-hTNF therapeutics.
Download the whitepaper to learn more on:
- The disease model
- Study design
- Routes of administration
- Validation data
- Analysis options