Biomedcode has developed a new humanized mouse line overexpressing human IL23p19. These mice develop spontaneous phenotypes including dermatitis lesions in jaw-neck area, ear thickening, enlarged draining lymph nodes, spleenomegaly and more. The skin pathology, that has features of atopic dermatitis, gets significantly ameliorated upon treatment with  anti-hIL23p19, rendering this mouse model a nice tool for the efficacy evaluation of therapeutics targeting this key molecule.

While the phenotypes are  further analyzed the dermatitis model  is available for preclinical evaluation.