Preclinical Platfrorms

Biomedcode offers preclinical testing of human therapeutics using standardized and validated preclinical platforms based on humanized and wild type mouse models of chronic and acute inflammatory diseases closely recapitulating human pathologies.

Disease Indications

  • Arthritis
  • Spondyloarthritis
  • Psoriasis
  • Osteoporosis
  • IBD
  • Multiple Sclerosis
  • Acute inflammation
  • Cancer
  • Infectious diseases

Routes of Administration

  • Intraperitoneal
  • Subcutaneous
  • Intradermal
  • Per Os
  • Intravenous
  • Intraarticular
  • Intratracheal
  • Implantation

Analysis options

  • In vivo scoring
  • Histopathology
  • uCT imaging
  • PK/PD sampling
  • Tissue collection
  • ELISA analysis
  • FACS analysis
  • Pharmacogenomis

Our success stories

  • Biesemann et al. 2023. Additive efficacy of a bispecific anti-TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis Sci Transl Med 15(681):eabq4419. PMID: 36724239.
  • Ishiwatari-Ogata et al. 2022. Ozoralizumab, a Humanized Anti-TNFα NANOBODY® Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG. Front. Immunol 13 – 2022 |
  • Yun-Chi Lu et al. 2019. Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy. PLoS Biol 17(6):e3000286.  PMID: 31194726
  • Obinna C Ubah et al. 2019 An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model. Front Immunol 10:526.  PMID: 30967865
  • Moore AR et al (2014). Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFα in rheumatoid 
arthritis. J Transl Med, 12(1):285.
  • Hofmann HP et al. (2016). Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel®).  Expert Opinion on Biological Therapy, 16(10)10.
  • Gabriel D et al. (2016). Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis. J Control Release. S0168-3659(16)30702-7.