The TNFΔARE mouse model develops arthritis pathology together with Crohn’s like ileal inflammation with 100% penetrance. The co-occurence of two inflammatory pathologies provide a reliable in-vivo model for evaluating therapeutics targeting both pathologies.

Grip strength force modulation with age in wt and TNFΔARE mice treated or not with Enbrel 


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  • The disease model
  • Study design
  • Routes of administration
  • Validation data
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