Tag Archives: bleomycin

BiomedcodeBiomedcode / bleomycin
20
May
2026
Date May 20, 2026
Categories News

A new preclinical platform for the evaluation of therapeutics targeting scleroderma.

Scleroderma or systemic sclerosis is a rare connective tissue disorder with complex pathogenesis. Scleroderma can be divided in localized scleroderma primarily affecting the skin and subcutaneous tissue, whereas systemic sclerosis is associated with systemic manifestations and involvement of multiple organ systems, including kidney, lung, heart, gastrointestinal tract and more.

To support the development of antifibrotic therapies that will be effective in the treatment of scleroderma we have developed and standardized the bleomycin induced scleroderma animal model,  that reproduces the pathology manifestations and is widely use in preclinical research.

The scleroderma model induced by mini osmotic pump released bleomycin  integrates comprehensive histopathological and molecular readouts of fibrosis and inflammation, providing a well-established and highly translational in vivo preclinical platform for evaluating novel therapeutics targeting fibrosis.

 

Author biomeduser
19
May
2025
Date May 19, 2025
Categories News

Bleomycin induced pulmonary fibrosis -a powerful preclinical tool for the evaluation of anti-fibrotic therapeutics.

🫁 Idiopathic Pulmonary Fibrosis (IPF) remains one of the most devastating chronic lung diseases, driven by complex dysregulated pathways involving multiple cell types, including macrophages, fibroblasts, and epithelial cells. Characterized by progressive lung inflammation and scarring, IPF continues to present significant challenges for patients due to limited therapeutic options.

💊Advancing effective anti-fibrotic therapies requires reliable and translational preclinical models that can accurately capture disease biology and support robust efficacy evaluation before clinical development.

The bleomycin-induced IPF mouse model developed in Biomedcode integrates comprehensive histopathological and molecular readouts of fibrosis and inflammation, providing a well-established and highly translational in vivo preclinical platform for evaluating novel therapeutics targeting fibrosis.

 

Author biomeduser

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